Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes

Inclusion Criteria: * Male or female, age 20 or over * Patients with moderate to severe dry eye(DEWS Level II or over) * Be informed of the nature of the study and will give written informed consent Exclusion Criteria: * Being treated with steroidal eye drop or non-steroidal anti-inflammatory eye drop for dry eye * Being treated with systemic steroid or immunosuppressive * History of eyeball surgical operation within 6 months * Wearing contact lenses during participation of the study * Pregnancy or breastfeeding * Use of cyclosporine eye drop within 2 weeks * Intraocular pressure(IOP)\> 25 mmHg * History of punctal occlusion within 1 month or during participation of the study * Hypersensitivity to the investigational products or be suspicious to them * Patients whom the investigator considers inappropriate to participate in the study