Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors

Inclusion Criteria * Male or female ≥18 years old * Patients with histologically confirmed solid tumors who: o Part 1: have tumor progression following standard therapy, have treatment-refractory disease, or for whom there is no effective standard of therapy * Women of child-bearing potential must have a negative pregnancy test within 7 days of initiation of dosing and must agree to use an acceptable method of birth control. Women of non-childbearing potential may be included if they are either surgically sterile or have been postmenopausal for ≥1 year. Fertile men must also agree to use an acceptable method of birth control while on study drug and up to 3 months after the last dose of study drug. * All associated toxicity from previous or concurrent cancer therapy must be resolved (to ≤Grade 1 or Baseline) prior to study treatment administration * Patients with stable, treated brain metastases are eligible for this trial. However, patients must not have required steroid treatment for their brain metastases within 30 days of Screening. * Willing and able to provide written informed consent prior to any study related procedures and to comply with all study requirements * Karnofsky performance status ≥70% * Life expectancy ≥3 months * Adequate hematologic, hepatic, and renal function Exclusion Criteria * Other than the primary malignancy, active cancer (either concurrent or within the last 3 years) that requires non-surgical therapy (e.g., chemotherapy or radiation therapy), with the exception of surgically treated basal or squamous cell carcinoma of the skin, melanoma in situ, or carcinoma in-situ of the cervix * Chemotherapy within 28 days prior to C1D1 * Biological therapy within 5 half-lives prior to C1D1 * Radiation therapy within 28 days or 5 half-lives prior to C1D1, whichever is longer * Investigational drug use within 28 days or 5 half-lives, whichever is longer, prior to C1D1 * Part 1 only: (a) Patients with active or a history of glucose intolerance or diabetes mellitus and (b) Hemoglobin A1c ≥7% * ≥Grade 2 sensory neuropathy at baseline * Uncontrolled intercurrent illness (i.e., active infection) or concurrent condition that, in the opinion of the Investigator, would interfere with the study endpoints or the patient's ability to participate * Refractory nausea and vomiting, malabsorption, small bowel resection that, in the opinion of the Investigator, would preclude adequate absorption * Mean QTcF ≥450 msec (for males) or ≥470 msec (for females) at Screening * The presence of a medical or psychiatric condition that, in the opinion of the Principal Investigator, makes the patient inappropriate for inclusion in this study