RSV001 - A New Vaccine to Prevent Severe Viral Chest Infections.

Inclusion Criteria: Participants must satisfy all of the following criteria to be considered eligible for the study: * Willing and able to give informed consent for participation in the study * Aged between 18 and 50 years (Groups 1-4) or aged 60-75 years (Groups 5-9) * In good health as determined by * Medical history * Physical examination * Clinical judgment of the investigators * Willing to use effective contraception * Females: The oral contraceptive pill, contraceptive implant or barrier methods from one month prior and for the duration of the study (Groups 1-4 only) * Males: Barrier contraception from V1 until 3 months after the last vaccination * Able to attend the scheduled visits and to comply with all study procedures * Willing to allow his or her General Practitioner and/or Consultant, if appropriate, to be notified of participation in the study * Confirmation from GP that they are aware of the inclusion and exclusion criteria and are satisfied from their knowledge of the volunteer that they are suitable to enroll * Willing to provide their National Insurance/Passport number for the purpose of TOPS registration Exclusion Criteria: The participant may not enter the study if any of the following apply: * History of significant organ/system disease that could interfere with trial conduct or completion. This includes any history of significant disease in the following; * Cardiovascular disease including congenital heart disease, previous myocardial infarction, valvular heart disease (or history of rheumatic fever), previous bacterial endocarditis, history of cardiac surgery (including pacemaker insertion), personal or family history of cardiomyopathy or sudden adult death * Respiratory disease such as asthma (excluding childhood asthma not treated in adulthood) and chronic obstructive pulmonary disease * Endocrine disorders such as diabetes mellitus and Addison's disease * Significant renal or bladder disease, including history of renal calculi * Biliary tract disease * Gastro-intestinal disease such as inflammatory bowel disease, abdominal surgery within the last two years, coeliac disease and liver disease * Neurological disease such as seizures and myasthenia gravis * Metabolic disease such as glucose-6-phosphate dehydrogenase deficiency * Psychiatric illness requiring hospitalization or depression whose severity is deemed clinical significant by the Chief Investigator, Consultant or GP * Non-benign cancer, including squamous cell carcinoma, basal cell carcinoma of the skin and cervical carcinoma in situ * Clinically significant contact dermatitis * Have any known or suspected impairment or alteration of immune function, resulting from, for example: * Congenital or acquired immunodeficiency * Human Immunodeficiency Virus infection or symptoms/signs suggestive of an HIV-associated condition * Autoimmune disease * Receipt of immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 12 months or long-term systemic corticosteroid therapy * Receipt of immunoglobulin or any blood product transfusion within 3 months of study start * A vaccination history indicative of; * Planning to receive any vaccine other than the study vaccine within 4 weeks following vaccination * A history of anaphylaxis reaction to a vaccine * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine, e.g. Kathon * Previously having received a recombinant simian or human adenoviral vaccine * Previously having received a recombinant MVA vaccine * Detection of any of the following at screening * IgA deficiency * Anti-HIV antibody * Hepatitis B surface antigen * Anti-HCV antibody * Any other significant abnormalities on screening investigations at the discretion of an Investigator * Known or suspected drug and/or alcohol misuse (alcohol misuse defined as an intake exceeding 42 units per week) * Nasal septal pathology including * Congenital deformities such as an abnormal septum or polyps * Previous cauterization, rhinoplasty or surgery of any kind * Recurrent epistaxis * Scheduled procedures requiring general anaesthesia during the study * Participation in another research study involving an investigational product in the past 12 weeks, or are planning to do so within the 20 weeks of this study * Inability, in the opinion of the Investigator, to comply with all study requirements * Female participants who are pregnant, lactating or planning pregnancy during the course of the study * Has donated blood within 4 months before starting the trial, or is intending to donate blood during the trial and up to 12 weeks after completing the study * Any other significant disease or disorder which, in the opinion of the Investigator, may * Put the participants at risk because of participation in the study * Influence the result of the study * Impair the participant's ability to participate in the study