Impact of a Short-Term High Fat or Low Fat Diet on Intestinal Genes Expression Involved in the Cholesterol and Fatty Acid Metabolism

Inclusion Criteria: * Males 18 to 50 years of age * Non-smoker * Body mass index between 20.0 and 30.0 kg/m2 * Plasma LDL-cholesterol levels between the 25th and 75th percentile for their age at day -14 * Plasma triglyceride levels \< 1.7 mmol/L (150 mg/dl) at day -14 * Plasma HDL-cholesterol levels between 0.9 (35 mg/dl) and 1.6 mmol/L (60 mg/dl) at day -14 * Subjects must be willing to give written informed consent and able to adhere to the diet schedule and visit schedule * Patients should be otherwise healthy, without elevations in hepatic transaminases or creatine kinase (CK) or abnormal renal function or coagulation Exclusion Criteria: * Patients with extreme dyslipidemias, such as familial hypercholesterolemia will be excluded * Subjects will be excluded if they have cardiovascular disease (CHD, cerebrovascular disease or peripheral arterial disease) or if they are taking other medications known to affect lipoprotein metabolism (eg. steroids, beta blockers, thiazide diuretics, other lipid lowering agents, significant alcohol intake etc.)