Safety, Immunogenicity And Efficacy Of Vaccination In Military Personnel

University of Roma La Sapienza262 enrolled

Overview

The purpose of this study is to determine if multiple vaccination in military personnel may be correlated with the appearance of poorly defined diseases as symptomatic multisyndrome, autoimmune or lymphoproliferative disorders. At the same time, considering possible interference between different vaccines, proteins and polysaccharides, living and inactivated, the study aims to assess the immunogenicity and efficacy also in relation to the specific Human Leucocyte Antigens (HLA) genetic structure.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

262

Conditions

Vaccination Adverse Events Vaccination Failure Specific Antibody Response

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Military volunteers * No recently immunized Exclusion Criteria: * Pregnancy * Documented immunodepression * Documented allergy or hypersensitivity to vaccines

Outcomes

Primary Outcomes

immunomediated disorders related to multiple vaccination

Time frame: three years

Secondary Outcomes

efficacy of multiple vaccination

Time frame: Three years

immunogenicity of multiple vaccination