Function and Modulation of Fibulin-1 Assembly in Nucleus of Corneal Fibroblasts

Far Eastern Memorial Hospital5 enrolled

Overview

The purpose of this study is to investigate the role of nuclear Fibulin-1 (FBLN1) in Human Corneal Fibroblasts under treatment of mitomycin C (MMC).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Function of Mitomycin C in Cornea

Interventions

Mitomycin CDRUG

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The frozen storage cells in liquid nitrogen were amplified from the residual corneal rim of the donors with more than 20 years old following penetrating keratoplasty. Exclusion Criteria: * The donors were younger than 20 years old.

Outcomes

Primary Outcomes

Modification of nuclear Fibulin-1 accumulation in suppressing gene expression

Time frame: 3 days post mitomycin C treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.