Neural Functioning of Feeding Centers in Obese Youth

Yale University51 enrolled

Overview

To explore whether obese adolescents with insulin resistance and relative low leptin levels exhibit functional alterations of the neuronal circuits involved in the regulation of energy metabolism and food seeking behaviors. We here propose to test the hypothesis that the reward circuitry is dysregulated in obese adolescents and is related to the degree of insulin resistance and hyperinsulinemia.

Functional Magnetic Resonance Imaging (fMRI) provides a non-invasive method to assess the functional pathways affected by nutrient ingestion and therefore can help answer important questions regarding potential differences in the response of brain regions involved in feeding.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Insulin Resistance

Eligibility

Sex: ALLMin age: 12 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Obese adolescents * Good general health, * taking no medication on a chronic basis * Age 12 to 17 yrs, * in puberty (girls and boys: Tanner stage II - IV) Obese Insulin Resistant Adolescents * (BMI\> 95th) * (WBISI\<1.2 plus a low adiponectin \<6 ug/dl and * high triglyceride levels \>130mg/dl) Obese Insulin Sensitive Adolescents * (BMI\>95th) * (WBISI \>3) plus high adiponectin \>8 ug/ml and * triglyceride levels \> 80 mg/dl Girls who begin menstruating must have a negative pregnancy test during the study Eligibility criteria for healthy non-obese children and adolescents: * Brother or sister with obesity * Age 12 to 17 years * Normal fasting glucose and lipids in the child, and * normal OGTT * No use of any medication known to affect glucose, lipid metabolism and inflammation * No endocrinopathies * No use of any antipsychotic medication * BMI \>25th to \<75th ( Center for Disease Control (CDC) BMI Charts) * Minimum weight of 90lbs (CDC Growth Charts) Exclusion Criteria * Baseline creatinine \>1.0 mg * Pregnancy * Presence of endocrinopathies (e.g. Cushing syndrome) * Cardiac or pulmonary or other significant chronic illness * Adolescents with psychiatric disorder or with substance abuse determined via self-report. * Use of anorexic agents No metal implants

Locations (1)

Yale University

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

measure of cerebral blood flow response to glucose ingestion

fmri on 3T to measure blood flow response after ingestion of glucose drink

Time frame: Baseline and 2 year follow up

Secondary Outcomes

measure of cerebral blood flow response to fructose ingestion

fmri on 3T to measure blood flow response after ingestion of fructose drink

Time frame: Baseline and 2 year follow up

Data from ClinicalTrials.gov

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