Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis

Inclusion Criteria: * Subjects who understand and sign the consent form for this study. * Age: 40-70, males and females. * Clinical diagnosis of degenerative arthritis by Radiographic Criteria of Kellgren and Lawrence. * Patients who can't treat with traditional medication and need a arthroplasty. * Duration of pain over Grade 4(11-point numeric scale)\> 4 months. Exclusion Criteria: * Women who are pregnant or breast feeding or planning to become pregnant during the study. * Objects who administer with a anti-inflammatory drugs within 14 days prior to inclusion in the study. * History or current evidence of alcohol or drug abuse or is a recreational user of illicit drugs or prescription medications. * Treatment with intra-articular injection therapy within 2 months prior to screen. * Other joint diseases except degenerative arthritis : systemic or rheumatic or inflammatory chondropathy, chondrocalcinosis, hemachromatosis, inflammatory joint disease, avascular necrosis of the femoral head, Paget's disease, hemophilic arthropathy, infectional arthritis, Charcot's disease, villonodular synovitis, synovial chondromatosis. * Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg, Anti-HCV-Ab), Hepatitis C (Anti-HCV-Ab) and syphilis. * Serious pre-existing medical conditions like Cardiovascular Diseases, Renal Diseases, Liver Diseases, Endocrine Diseases, Cancer and Diabetes Mellitus. * Overweight expressed as body mass index (BMI) greater than 30 (obesity grade II). * Participation in another clinical trial or treatment with a different investigational product within 3 months prior to inclusion in the study. * Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria.