Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus

Isfahan University of Medical Sciences22 enrolled

Overview

The purpose of this study is to determine which surgical method makes less corneal haze

Keratoconus is an asymmetric, bilateral, progressive non-inflammatory ectasia of the cornea. The investigators evaluate whether partial removal versus total removal of the corneal epithelium can lead to less corneal haze and better visual outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Keratoconus

Interventions

collagen cross-linking procedure (total removal)PROCEDURE

patients underwent Corneal collagen cross-linking procedure with totally corneal epithelium removing. Total removal was performed by mechanical debridement of the corneal epithelium over the central 9 mm.

collagen cross-linking procedure (partial removal)PROCEDURE

patients underwent Corneal collagen cross-linking procedure with partially corneal epithelium removing. Partial removal was performed by removing a 3-mm width ring and leaving the central 3 mm of the cornea intact.

Eligibility

Sex: ALLMin age: 16 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 16-40 years * axial topography consistent with keratoconus * minimum corneal thickness more than 400 µm and a progression of keratoconus in past 12 months Exclusion Criteria: * history of ocular herpes or non-healing corneal ulcers * subjects with current ocular infection * severe preoperative corneal haze or scar * severe ocular surface disease * autoimmune diseases * pregnant women

Locations (1)

Feyz university hospital

Isfahan, Isfahan, Iran

Outcomes

Primary Outcomes

Best corrected visual acuity

determining corrected visual acuity in partial removal versus total removal of the corneal epithelium

Time frame: at six months after surgery

Secondary Outcomes

Corneal optical density

Corneal optical density was assessed by Scheimpflug densitometry

Time frame: at six months after surgery

Data from ClinicalTrials.gov

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