A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)

University of Kansas12 enrolled

Overview

Recent evidence has shown that kidney volume predicts the likelihood of developing renal insufficiency over a finite length of time in ADPKD, suggesting a linkage between the growth of cysts and the harm they do to kidney function. Recent studies indicate that the rate of kidney volume increase is hastened by excess dietary protein, salt, and potential net acid precursors, and slowed by increased water intake sufficient to lower plasma vasopressin levels. Diets are commonly prescribed to treat ADPKD and other renal patients with disease near the end-stage, but there is currently no specific diet prescription that takes potentially harmful dietary elements into account for ADPKD patients in the earliest stages of the disease. This study will examine a novel diet for ADPKD created by the researcher termed the ADPKD diet.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Autosomal Dominant Polycystic Kidney Disease

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Have not been prescribed dietary restrictions or enhancements * Blood pressure \<135/85 mmHg with or without specific treatment * Willingness to participate for at least one month * Diet history consistent with the excretion of \>30 mEq NAE / day based on usual dietary intake Exclusion Criteria: * Other active diseases requiring pharmacologic agents * Unstable weight (+/- 2 kg) for 3 months prior to enrollment * Food allergies * Pregnancy or lactating * Confounding medications, i.e. bicarbonate, citrate * Individuals who do not consume meat for personal, religious, or health reasons.

Outcomes

Primary Outcomes

ADPKD diet impact on net acid excretion

The difference in net acid excretion from a participants regular diet and the ADPKD diet

Time frame: Change from Baseline to Day 36

Secondary Outcomes

Acceptance of ADPKD diet

Ease with which diet will be embraced by participants

Time frame: 36 days

Kidney injury markers

Change in urine markers of renal injury in participants