Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Marmara University100 enrolled

Overview

Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Thyroid Cancer Breast Cancer

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent Exclusion Criteria: * ones who did not sign the consent form NSAID or steroid users

Locations (1)

Marmara University School of Medicine

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis

participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.

Time frame: up to 3 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.