Painful Knee Prosthesis. Relationship Between Endogenous Analgesia and Persistent Post Surgical Pain.

Parc de Salut Mar180 enrolled

Overview

This is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; TKA) and the probability to develop chronic pain after surgery (persistent post surgical pain). Endogenous analgesia efficiency will be measured during the month previous to surgery using quantitative sensory testing (QST). Persistent post surgical pain will be defined as presence of pain in movement greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Knee Osteoarthritis

Interventions

Quantitative sensory testing (QST)BEHAVIORAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Older than 18 patients * Scheduled for primary total knee arthroplasty * Disposition to visits and scheduled tests Exclusion Criteria: * Previous surgery on knee to be operated * Documented peripheral neuropathy * Severe disease or condition that could potentially interfere with interpretation of tests.

Locations (1)

Servicio d'Anestesia i Reanimació, Hospital del Mar

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

Presence of pain in the operated knee, 6 months after surgery.

Time frame: Presence of pain greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.

Secondary Outcomes

Endogenous Analgesia efficiency measured with QST (Quantitative sensory testing) techniques.

Time frame: From start of recruitment untill day 180.

Data from ClinicalTrials.gov

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