The purpose of this study is to investigate the influence of hypoalbuminemia on the protein binding characteristics of the antifungal drug voriconazole in ICU patients.
Study Type
OBSERVATIONAL
Enrollment
35
During the treatment of voriconazole, at steady plasma concentrations of voriconazole, one plasma sample and one serum sample are taken.
University Hospitals Leuven
Leuven, Vlaams-Brabant, Belgium
Differences in Overall Protein Binding in the Presence of Different Plasma Albumin Concentrations.
At steady state plasma concentrations of voriconazole, a plasma sample is taken to determine the overall protein binding of voriconazole. Equilibrium dialysis is used, followed by liquid chromatography-mass spectrometry.
Time frame: At steady state plasma concentration of voriconazole (after day 4 of therapy)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.