Our study will investigate inhalation therapy of NaCl 3% compared to standard therapy with no inhalation in the treatment of moderate to severe bronchiolitis. The impact on length of hospital stay will be analyzed.
Acute viral bronchiolitis is the most common lower respiratory tract infection in the first year of life and leads to a large number of hospital admissions. The only recommended treatment is supportive. However many different types of drug inhalations have been studied but their efficacy remains controversial. Our study will compare recommended supportive therapy to supportive therapy combined to hypertonic saline (NaCl 3%) inhalations in the treatment of moderate to severe bronchiolitis. This will be the first study to use a true control group with no inhalation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
NaCl 3%: 4ml QID
Standard therapy includes suctioning nasal secretions, water-electrolyte balance maintenance and oxygen supplementation when needed
Hôpital de l'Enfance
Lausanne, Canton of Vaud, Switzerland
length of hospital stay
The length of stay is defined as the time between study entry and the time at which the child reach protocol-defined discharge criteria as measured by the physician in charge.
Time frame: 2 years
transfer rate to ICU
Time frame: 2 years
readmission rate in the next 7 days following discharge
Time frame: 2 years
Wang clinical severity score evolution
Time frame: 2 years
adverse events
Time frame: 2 years
Patients' ability to feed
Time frame: 2 years
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