Background Familial hypercholesterolemia (FH) is an inherited disease in which the level of bad cholesterol (LDL-cholesterol) is increased, leading to an increase in coronary heart disease even if adequately treated with cholesterol lowering medication (statins). Polyunsaturated fatty acids (PUFA) including omega-3 is known to affect the risk for coronary disease, however its effect on patients with FH is not known. The purpose of the study is to assess the effect of PUFA on patients with FH, with regard to inflammation measured in the blood and the effect on the blood vessels'ability to relax (endothelial function) by means of tonometry. Hypothesis Treatment with 4 grams of PUFA a day for 4 months will lead to an improvement in the endothelial function, and the treatment will also lead to a decrease in in several markers of inflammation and in lipids in the blood.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
34
Division of Internal Medicine, Nordland Hospital
Bodø, Norway
Reactive Hyperemia Index (RHI)
Reactive Hyperemia Index (RHI) is a measure for endothelial function by means of tonometry
Time frame: Baseline
Reactive Hyperemia Index (RHI)
Measure of endothelial function
Time frame: 3 months
Reactive Hyperemia Index (RHI)
Measure of endothelial function
Time frame: 6 months
Reactive Hyperemia Index (RHI)
Measure of endothelial function
Time frame: 9 months
Markers of inflammation
Serological markers of inflammation including cytokines, C-reactive protein (CRP) and complement factors
Time frame: Baseline
Inflammatory markers
Serological markers of inflammation including cytokines, CRP and complement factors
Time frame: 3 months
Inflammatory markers
Serological markers of inflammation including cytokines, CRP and complement factors
Time frame: 6 months
Inflammatory markers
Serological markers of inflammation including cytokines, CRP and complement factors
Time frame: 9 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.