The Efficacy of Additional Intravesical Instillation of Hyaluronic Acid/Chondroitin Sulfate to Transurethral Resection of Bladder Ulcer in Patients With Interstitial Cystitis/Bladder Pain Syndrome.

Inclusion Criteria: 1. must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2. Pain VAS ≥4 3. O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4. PUF score ≥ 13 5. cystoscopic record within 2 years 6. Hunner ulcer lesion in cystoscopic finding Exclusion Criteria: 1. Scheduled for or use of intravesical therapy (eg, bladder distention,transurethral resection of bladder ulcer, instillation) during or within 6months prior to the study and use of pentosan polysulfate sodium within 1 months prior to the study 2. Patients who are pregnancy or, childbearing age without no contraception 3. Patients with voided volume \<40 or, \> 400ml 4. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination 5. Patients with urine culture showing evidence of urinary tract infection 1month prior to the study 6. Accompanied medical problem below * Tuberculosis in urinary system * Bladder cancer, urethral cancer, prostate cancer * Recurrent cystitis * anatomical disorder 7. Patients had prior surgery (eq, bladder augmentation, cystectomy 8. Patients with neurologic disorder 9. Patients with indwelling catheter or intermittent self-catheterization 10. Patients with psychologic problem