Methamphetamine substance use is common worldwide. No approved pharmacologic treatments for methamphetamine dependence exist. Aripiprazole are Second generation antipsychotics，but have different pharmacological effects of neurotransmitters.To determine whether mirtazapine would reduce methamphetamine use among mehtamphetamine addicts.
Methods:A Multiple-Center, Randomized, Double-Blind.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
Aripiprazole group,5mg/pill,10mg/day non-forced titration method,last 12weeks
placebo group,5mg/pill,10mg/day non-forced titration method,last 12 weeks
The Second Xiangya Hospital of Central University
Changsha, Hunan, China
abstinent time of Methamphetamine addict
methamphetamine-positive urine test results,self-reports of substance use
Time frame: up to 3 months
number of Participants with Adverse Events as a Measure of Safety and Tolerability
use Abnormal Involuntary Movement Scale ,Simpson-Angus Scale and Barnes akathisia Scale
Time frame: up to 3 months
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