Role of Neutrophil Activation

Washington University School of Medicine82 enrolled

Overview

Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique. Specimen samples obtained by wall suction will be collected at 2 time points following intubation. Blood samples will be obtained at 2 time points, simultaneous with the collection of the tracheal specimens.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Patients Requiring Endotracheal Intubation

Interventions

tracheal lavagesPROCEDURE

tracheal lavages obtained during endotracheal intubation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria 1. Ages 18 to 65 2. American Society of Anesthesiologists Physical Status Classification (ASA) I and II 3. Required to have endotracheal intubation 4. Scheduled for short admission (\<23 hrs), or ambulatory orthopedic surgery (ankle, shoulder, or extremity surgery); general surgery (exploratory laparotomy, cholecystectomy, ventral or inguinal hernia repair); obstetric/gynecological surgery(total abdominal hysterectomy, bilateral salpingo-oophorectomy); urologic surgery (nephrectomy, prostatectomy), lumbar spine surgery( discectomy, one or two level lumbar fusion) procedures. 5. Estimated duration of surgery 3 to 4 hours. 6. Provide informed consent Exclusion Criteria 1. Active pulmonary disease within 5 days prior to enrollment 2. On immunosuppressive medications 3. Previous tracheal surgery 4. On azithromycin 5. Diabetes 6. Pregnancy 7. Smoking history of less than 6 weeks prior to surgery 8. Surgery or intubation within 5 days of surgery 9. Planned surgical procedure involving neck or thoracic regions 10. Active pulmonary disease 11. Autoimmune disease (HIV, AIDS, Rheumatoid Arthritis 12. Hepatitis 13. Cancer

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Neutrophil Cell Counts in Tracheal Lavages

Neutrophil cell count were collected after an average of 3.2 hours of exposure to an ETT. Cell counts were performed using 10x6 per ml

Time frame: average of 3.2 hours of exposure to an ETT

Secondary Outcomes

Intubation Time in Minutes

Average amount of time that participants were intubated

Time frame: Up to 363 minutes for intubation time

Data from ClinicalTrials.gov

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