The purpose of this study is to access the effects of Enhanced External Counterpulsation treatment on lower urinary tract symptoms in patients with benign prostatic hyperplasia.
Patients with benign prostatic hyperplasia and will be randomized into two groups: EECP intervention or not. Lower urinary tract symptoms, hemodynamic parameters, vascular endothelial function will be measured and compared
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Enhanced external counterpulsation (EECP) is mainly used in cardiovascular and cerebrovascular diseases, which has been proven to be able to improve microcirculation and endothelial function. EECP therapy is done by sequential inflation of 3 sets of cuffs wrapped around the lower extremities during diastole and deflation of the cuffs during systole. The systolic deflation/ Diastolic inflation sequence of EECP leads to systolic unloading and diastolic augmentation, resulting in increased blood flow in a pulsatile manner. The patients will receive 35-36 hours EECP intervention, 1-hour session every day over a 7-week period.
The First Affiliated Hospital, Sun Yat- sen University
Guangzhou, Guangdong, China
RECRUITINGChange from baseline in lower urinary tract symptoms evaluated by International Prostate Symptom Score
Time frame: 7 weeks
Urinary flow rate
Change from baseline in urinary flow rate
Time frame: 7 weeks
Endothelial function
Change from baseline in flow- mediated dilation (FMD) accessed by color Doppler ultrasound system
Time frame: 7 weeks
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