The idea is to assess the predictive value of flow magnetic resonance imaging (flow MRI) for patient suffering normal pressure hydrocephalus (NPH) planned for surgery. By now, the depletive lumbar puncture is the best test assessing the efficacy of a forthcoming surgery. The idea is to demonstrate that flow MRI can be as effective as lumbar puncture in term of predictive value of surgery response. In that way, cerebrospinal fluid (CSF) dynamics are evaluated by a single non invasive examination. CSF flow is measured at the Sylvius' aqueduct, cervical, arachnoid space and 4th ventricle levels.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
30
Quantitative CSF flow study was performed by 2D phase-contrast velocity-encoded cine MRI (repetition/echo time, 15/7 ms; field of view = 140 x 140 mm²; matrix size = 256 x 128, flip angle = 25 degrees,one excitation, slice thickness = 5 mm). Cerebrospinal fluid flow was measured with a velocity-encoding value of 10-20 cm/s. Peripheral gating was used to cover the entire cardiac cycle with retrospective cardiac synchronization of 32 quantitative flow-encoded images per cycle. Clinical examination consists in neuropsychological assessment (including mini mental state examination test and Bradley's scale) as well as Hakim's triad evaluation
CHU Amiens
Amiens, Picardie, France
CSF stroke volume
Measurement of CSF stroke volume via flow MRI at the Sylvius' aqueduct level
Time frame: Day 1
Hakim's triad evaluation
Assessment of the signs of normal pressure hydrocephalus
Time frame: Day 1
Hakim's triad evaluation
Assessment of the signs of normal pressure hydrocephalus (follow-up)
Time frame: Day 90
Hakim's triad evaluation
Assessment of the signs of normal pressure hydrocephalus (follow-up)
Time frame: Day 365
Neuropsychological test
classical neuropsychological assessment (including mini mental status evaluation)
Time frame: Day 1
Neuropsychological test
classical neuropsychological assessment (including mini mental status evaluation) (follow up)
Time frame: Day 90
Neuropsychological test
classical neuropsychological assessment (including mini mental status evaluation) (follow up)
Time frame: Day 365
CSF stroke volume
Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up)
Time frame: Day 60
CSF stroke volume
Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up)
Time frame: Day 365
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