This is a clinical study to evaluate the effect of CMPN (Chronic myeloproliferative neoplasm) to the bone. The hypothesis is that patients with CMPN have a higher fracture-rate compared to the background population. We expect to find a lower BMD using conventional DXA scan (dual energy x-ray absorptiometry), and a change in other parameters using HR-pQCT (high-resolution peripheral quantitative computerized tomography).Biochemical bone markers is measured to support the hypothesis.
This is a clinical study to evaluate the effect of CMPN to the bone. Three individual cohorts are defined; a cohort consisting of 50 patients with Polycythemia Vera (PV), a cohort consisting of 50 patients with Essential Thrombocythemia (ET), and a cohort consisting of 25 patients with Primary Myelofibrosis (PMF). Patients are recruited from the Department of Hematology, Odense University Hospital. Interventions consist of: * Conventional DXA scan to measure Bone Mineral Density (BMD). * Experimental HR-pQCT to assess geometry, strength and microstructure of the bone in 3 dimension. * Blood-samples are collected and frozen for later analyses of Biochemical Bone Markers: 1-CTP, Ctx, ALP (alkaline phosphatase)and P1NP. The outcome is compared to healthy control individuals.
Study Type
OBSERVATIONAL
Enrollment
125
Faculty of Health Sciences, Institute of Clinical Research
Odense, Region Syddanmark, Denmark
RECRUITINGBone Mineral Density (BMD)
Patients will undergo one DXA scan independent of time of CMPN diagnosis
Time frame: 1 day
Evaluation of Geometry, Strength and Micro-Structure of the bone.
Patients will undergo one HR.pQCT indepedent of the time of the diagnosis of CMPN
Time frame: 1 day
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