Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness

University Hospital, Akershus192 enrolled

Overview

The purpose of this study is to establish a reliable method for detection of rectal cancer patients with aggressive tumor at risk of metastatic disease and death by functional MRI.

Study Type

OBSERVATIONAL

Enrollment

192

Conditions

Rectal Diseases Rectal Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms

Interventions

new functional magnetic resonance imaging (MRI) protocolsPROCEDURE

diffusion-weighted MRI, dynamic-contrast enhanced MRI, MR spectroscopy, blood-level oxygen dependent (BOLD) MRI

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patient is willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee. * The patient has confirmed rectal cancer diagnosis and is scheduled to radical surgery alone or preoperative CRT followed by surgery. * The patient is ≥ 18 years. * The patient has no prior rectal cancer treatment. * The patient has adequate renal function: creatinine clearance ≥ 60 ml/minute. * The patient has signed the written informed consent according to the protocol approved by the Regional Ethics Committee. Exclusion Criteria: * The patient has contraindication to MRI or MRI contrast agent according to clinical practice. * The patient wants to withdraw for any reason during the study.

Locations (1)

Akershus University Hospital

Lørenskog, Akershus, Norway

Outcomes

Primary Outcomes

Presence of metastatic disease 5 years after rectal cancer treatment

Time frame: five years

Secondary Outcomes

Histomorphological response to preoperative chemoradiotherapy

Time frame: 8 weeks

Data from ClinicalTrials.gov

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