Neonates With Very Low Birth Weight and Surgery Therapy of Acute Abdomen

Charite University, Berlin, Germany89 enrolled

Overview

Objective: Due to high mortality rates the capillary leakage and the acute abdomen are important risk factors of the probability of survival. The aim of an optimal therapy of the acute abdomen within the neonatal period is beside the cure of the underlying disease the prophylaxis of capillary leakage with the help of optimised intra- and postoperative volume therapy. Question: Do the neonates with very low birth weight and a surgery therapy of acute abdomen benefit from early increase of the haemoglobin/haematocrit by optimised volume therapy with crystalloid and colloidal volume as prophylaxis of the capillary leakage?

Study Type

OBSERVATIONAL

Enrollment

Conditions

Very Low Birth Weight

Eligibility

Sex: ALLMin age: 1 MinuteMax age: 4 Weeks

Medical Language ↔ Plain English

Inclusion criteria: * All Children with very low birth weight who have undergone surgery of acute abdomen within the neonatal period between 2001 and 2011 on "Campus Charité Mitte" or "Charité Virchow - Klinikum". * Neonates (calculated date of birth + 4 weeks) Exclusion criteria: * Birth weight \> 1500g

Locations (1)

Department of Anesthesiology and Intensive Care Medicine, CCM and CVK, Charité - University Berlin

Berlin, State of Berlin, Germany

Outcomes

Primary Outcomes

Postoperative Capillary Leakage

Postoperative Capillary Leakage (defined as weight gain within 48 hours or development of oedema within 48 hours)

Time frame: 48 hours from Baseline (Operation)

Secondary Outcomes

Amount of transfusions during surgery

Time frame: Up to 5 hours

Re-surgery rate

Time frame: Participants will be followed for the duration of hospital stay, an expected average of 12 weeks

Length of stay

Time frame: Participants will be followed for the duration of hospital stay, an expected average of 12 weeks

Mortality

Time frame: Up to 1 year