Epidemiological Analysis of Vitamin D and Breast Cancer Risk in Saudi Arabian Women

University of Arizona240 enrolled

Overview

This is an analysis of de-identified data collected from 240 Saudi Arabian women, 120 with breast cancer and 120 control women, to evalyate if vitamin D status is associated with breast cancer risk.

Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian women are thought to be at greater risk for vitamin D deficiency due to darker skin type and greater likelihood for reduced UVB radiation exposure. However, there is a lack of data regarding the vitamin D status of Saudi Arabian women and how this may relate to breast cancer risk. Objective: The purpose of this research was to evaluate the association between circulating concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women. Design: A case-control study was conducted among 120 breast cancer cases and 120 controls. The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi Arabia from June to August 2009. Participants completed questionnaires on diet and medical history and serum samples were collected from all women to measure circulating 25(OH)D concentrations.

Study Type

OBSERVATIONAL

Enrollment

240

Conditions

Breast Cancer Vitamin D Deficiency

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Invasive breast cancer (cases) or healthy women (controls), * receiving standard medical check-ups at the women's clinic * Female, * between the ages of 18 and 75 years * BMI ≤ 40 kg/m2 * residence in Saudi Arabia for more than 5 years * absence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease. Exclusion Criteria: receiving standard medical check-ups at the women's clinic * Male, * less than 18 or greater than 75 years of age * BMI \> 40 kg/m2 * Not a resident of Saudi Arabia for more than 5 years * Presence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.

Locations (1)

University of Arizona

Tucson, Arizona, United States

Outcomes

Primary Outcomes

serum vitamin D

assessed serum vitamin D in cases versus controls

Time frame: cross-sectional from May 2009-August 2009

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.