Creatine Supplementation on Kidney Function in Resistance-trained Individuals

University of Sao Paulo46 enrolled

Overview

There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Healthy Persons

Interventions

creatineDIETARY_SUPPLEMENT

20 g/d for 5 d followed by 5 g/d throughout the trial

placeboDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * participation in recreational resistance training * consumption of a high-protein diet (≥ 1.2 g/Kg/d) Exclusion Criteria: * vegetarian diet * use of creatine supplements in the past 6 months * chronic kidney disease * use of anabolic steroids.

Locations (1)

Univsersity of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

kidney function

as assessed by 51Cr-EDTA clearance

Time frame: 3 months

Secondary Outcomes

proteinuria

Time frame: 3 months

albuminuria

Time frame: 3 months

serum urea

Time frame: 3 months

serum creatinine

Time frame: 3 months

Data from ClinicalTrials.gov

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