A Study of Local Effect and Safety of a Single PPC-5650 Dose on Reflux Pain During Pain Stimulation in the Esophagus

Inclusion Criteria: * Signed informed consent before any study specific procedures * Able to read and understand Danish. * Healthy i.e. no history of chronic or recurrent pain rewarding diseases * Able to co-operate and tolerate the experimental procedures (as assessed in the training visit) * No over the counter medication 24h before the three visits * No medications in the study period * BMI 18.5-35.0 * Caucasian * No symptoms of Gastroesophageal reflux disease * All men must use a safe method of contraception during the study period Exclusion Criteria: * Any clinically relevant abnormal values from the laboratory tests on hematology, clinical chemistry, and/or urine analyses, as judged by the investigator. * Participation in any other clinical trial within three months prior to the training day. * Alcohol or drug abuse. * Mental illnesses * Allergic to the active ingredient in the investigational medicinal product