Safety and Efficacy of Exjade in the Treatment of Transfusion-dependent Iron Overload in Aplastic Anemia Patients

Inclusion Criteria: * Main diagnosis: aplastic anemia * Absence of severe and/or uncontrolled comorbidities * Confirmed iron overload (serum ferritin ≥ 1000 mkg/L) * Serum creatinine is not higher than the upper limit of normal for the given age * Absence of severe proteinuria. Protein/Creatinine ratio should be \< 0.5 mg/mg * Liver enzymes are \< 5 ULN * Completion of a scheduled cycle of immunosuppressive treatment program, with no severe infectious or generalized hemorrhagic complications * WHO (ECOG) performance status ≤ 2 Exclusion Criteria: * No signed informed consent form * Patient is under 18 years old * Severe concomitant condition * Severe infectious and generalized haemorrhagic complication following regular planned cycle of programmed immune suppressive treatment. * History of increased sensitivity to active substance and any other ingredient of the medicinal product. * Creatinine clearance (CC) \< 60 ml/min and/or creatinine concentration in blood serum is 2 or more times higher than upper limit of age normal by results of 2 tests at Visits 1 and 2. * Severe liver disorders (class C by Child-Pugh scale). * Patients with aplastic anaemia in which chelator treatment will be ineffective due to rapid progression of the disease. * Significant proteinuria basing on protein creatinine ratio \> 1.0 mg/ml in urine sample from second urination at Visits 1 and 2 (or as an alternative in 2 of 3 urine samples at screening); * Rare hereditary disorders related to galactose intolerance, severe deficit of lactase or glucose-galactose malabsorption; * Pregnancy, lactation; * Level of liver enzymes higher than 5 upper limits of age normal at Visits 1 and 2.