Organ Donor Tissue Oxygen Saturation as a Predictor of Number of Organs to Transplant Per Donor

Number of organs with targeted end-organ function per donor

Normal end-organ function definitions 1. Kidney function: Creatinine ≤ 1.5 mg/dL, urinary output ≥ 0.5 ml/kg/h 2. Liver function: INR \<1.5, Prothrombin time: 8.4-13 seconds (or within normal range per testing lab). Bilirubin, AST, ALT within normal range per laboratory limits. 3. Lung function: PaO2/FiO2 index ≥ 300 with PEEP ≤ 8 (oxygen challenge gas) 4. Heart function: Normal systolic and diastolic function per echocardiogram with minimal inotropic/vasopressor support. Systolic function will be estimated by ejection fraction and/or shortening fraction on echocardiogram. Normal cardiac catheterization data if available 5. Pancreatic function: HbA1c\<6, amylase and lipase within normal range per laboratory limits. 6. Small intestine function: lactate ≤ 2.2 mmol/L with minimal vasopressor support.

Time frame: At the last hour at the Intensive Care Unit, before the donor is transferred to the operating room.

Number of organs predicted to be transplanted using organ donor calculator

Time frame: At the last hour at the Intensive Care Unit, before the donor is transferred to the operating room.

Correlation of tissue oxygenation readings to macro-hemodynamic measurements

Mean arterial pressure, central venous pressure, cardiac output, positive pressure variation, stroke volume variation

Time frame: During donor management until cardiac arrest at the operating room

Variation of tissue oxygenation after thyroid hormone is initiated, titrated and/or discontinued.

Time frame: During donor management until cardiac arrest at the operating room