Inpatient Closed-loop Glucose Control

Inclusion Criteria Subjects with type 1 diabetes * Age 21 to 75 with clinical type 1 diabetes for at least one year * Diabetes managed using an insulin infusion pump and rapid- or very-rapid-acting insulins * Total daily dose (TDD) of insulin that is \< 1 u/kg Subjects with type 2 diabetes * Age 21 to 75 with clinical type 2 diabetes for at least one year * Diabetes managed using NPH as the basal insulin, which may be supplemented with regular or rapid-acting insulin * Total daily dose (TDD) of insulin that is \> 1 u/kg/day but \< 2 u/kg/day or \> 2 u/kg/day Exclusion Criteria: * Pregnancy * Renal insufficiency * Cancer * Abnormal EKG suggestive of coronary artery disease or increased risk of malignant arrhythmia * Acute illness or exacerbation of chronic illness at the time of the study procedure * Use of non-insulin, injectable anti-diabetic medications or oral anti-diabetic medications other than metformin * History of allergy or adverse reaction to aspirin, peptic ulcers or bleeding disorders * Known history of coronary artery disease, TIA or stroke * History of seizures * Transaminitis * Stage 2 hypertension at the time of screening