Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

N/ACompletedNCT01819883

Massachusetts General Hospital40 enrolled

Overview

This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acromegaly

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 18 - 75 yr (both groups) * Study subjects with active acromegaly * Healthy controls Exclusion Criteria: * Serum creatinine or alanine aminotransferase (ALT) \> 2 times the upper limit of normal, metastatic cancer. * Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus. * Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers. * Pregnant women

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Change in Liver Fat

Change in intrahepatic fat after biochemical control of acromegaly

Time frame: Baseline and 3-month follow-up visit

Change in Thigh Muscle Cross-sectional Area

Change in thigh muscle cross-sectional area after biochemical control of acromegaly

Time frame: Baseline and 3-month follow-up visit

Data from ClinicalTrials.gov

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