Efficacy of Non Contrast DWI(Diffusion Weighted Imaging) Imaging Compared to DMR-DE

N/ACompletedNCT01820000

University of Michigan23 enrolled

Overview

Use of MRI and DWI to diagnose cardiac scarring after heart attack.

To discover new information about MRI (magnetic resonance imaging) called DWI (diffusion weighted imaging) and its ability to diagnose cardiac scarring. CMR-DE (cardiac MR with delayed contrast enhancement) evaluates if there has been scarring in the heart muscle following a heart attack. Subjects are injected with a contrast medication that makes the scarring visible if present. To prove the efficacy of DWI (diffusion weighted imaging) to provide the same images that CMR-DE (cardiac magnetic resonance with delayed contrast enhancement) provides.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Heart Attack

Interventions

Diffusion Weighted Imaging with MRI scansPROCEDURE

Subjects will have an MRI(magnetic resonance imaging)performed. This sequence will take no longer than 10 to 15 minutes to complete. Only DWI (diffusion weighted imaging) will be added to the standard cardiac MR protocol for viability which requires contrast injection. DWI(diffusion weighted imaging) sequence does not require contrast injection.

Eligibility

Sex: ALLMin age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males and females 21 years of age and older * Healthy volunteers * subjects with a prior history of heart attack and prior CMR-DE imaging. Exclusion Criteria: * Women who are pregnant * Subjects with GFR \< 60 ml/min/1.73m2 * Subjects with ICD * Subjects with coronary stents incompatible with 3T

Locations (1)

University of Michigan Hospital

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

presence and apparent diffusion coefficient (ADC) quantification of scar on (DWI) diffusion weighted image

Confirm the efficacy of diffusion weighted imaging in providing imaging that shows cardiac scarring without the injection of contrast.

Time frame: single occurance

Data from ClinicalTrials.gov

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