The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma

Inclusion Criteria: * FIGO stage: Ⅰ, endometrial carcinoma; * Female, Chinese women; * Initial treatment is staging surgery; * Pathological diagnosis: Endometrial adenocarcinoma; * Pathologic examination and meet the following one of the indications of adjuvant therapy: ① histopathological grading in poorly differentiated: G3; ② ≥50% myometrial invasion; ③ vascular space involvement; * No prior treatment; * Provide written informed consent. Exclusion Criteria: * Unable to receive surgery and/or unsuitable for radiotherapy or chemotherapy; * Family history of ovarian cancer; * Suffering from other malignancies; * Concurrently participating in other clinical trials; * Unable or unwilling to sign informed consents; * Unable or unwilling to abide by protocol.