Patients with a hematological malignancy who are undergoing intensive chemotherapy need a central venous catheter (CVC)during their treatment. CVCs are locked with heparin when they are not used. The purpose of this study is to determine whether concentrated citrate locking, compared to heparin, reduces the incidence of central venous catheter-related thrombosis and infections in patients with hematological malignancies undergoing intensive chemotherapy.
Central venous catheter (CVC)-related thrombosis and infections are frequently occurring complications and may cause significant morbidity in patients with hematological malignancies. Interventions to decrease fibrin deposition have the potential to reduce CVC-related thrombosis and infections. At present heparin is most often used as locking solution for central venous catheters in hematological patients despite a lack of evidence regarding the efficacy and safety. Trisodium citrate (TSC) had been shown to be an effective antimicrobial catheter locking in hemodialysis patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
212
when not in use CVCs are locked with heparin
when not in use the CVC is locked with concentrated citrate
Atrium Medical Center Parkstad Heerlen
Heerlen, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
central venous catheter-related thrombosis
Patients will be followed from insertion of the central venous catheter till removal of the central venous catheter, an expected average of 30 days. The central venous catheter is seen daily and checked for thrombosis and infections when the patient is admitted on the ward. Discharged patients are seen at least weekly on the outpatients clinic and their central venous catheter is checked for thrombosis and infections. A standard ultrasound is made 30 days after insertion and within 24 hours after removal of the central venous catheter.
Time frame: weekly from date of randomization until removal of the central venous catheter, up to one year
central venous catheter-related infections
Time frame: weekly from date of randomization untill the removal of the central venous catheter; up to one year
premature removal of the catheter
Time frame: weekly from date of randomization untill removal of the central venous catheter; up to one year
failure to aspirate blood
Time frame: weekly from date of randomization untill the removal of the central venous catheter; up to one year
hypocalcemic symptoms
Time frame: weekly from dateof randomization untill the removal of the central venous catheter; up to one year
severe bleeding
Time frame: weekly from date of randomization untill the removal of the central venous catheter; up to one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.