2 Phase Comparison of Pre-operative CT and PET Images for Metastatic Colorectal Cancer

Inclusion Criteria: * Patients with histologically-confirmed colorectal carcinoma and preoperative PET scan with evidence of hypermetabolic lesions suspicious for cancer will be eligible for this study. In cases of primary cancer, there must be a tissue-confirmed diagnosis. In recurrent cases, patients must have clinical evidence by CT or MRI of disease suitable for resection. * Patients must be candidates for clinically indicated surgery. * Patients with recurrent disease may have had prior surgery and/or chemotherapy with no limit to the number of prior therapeutic procedures or chemotherapeutic regimens. * Patients must have a performance status of 0, 1 or 2 by ECOG(Eastern Cooperative Oncology Group)standards. * Patients must give written informed consent including consent to have IV line placed for FDG administration. * Patients must be at least 18 years of age. Children under the age of 18 are excluded from the study due to the rarity of colorectal cancer in children. * Because radiolabeled agents are known to be teratogenic, women of child-bearing potential and men must agree to use an acceptable form of contraception prior to study entry and for the duration of the study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. * Organ function requirements: Patients must have organ and marrow function adequate to undergo laparotomy. Specifically: * Serum creatinine \< 2.0 mg/dl * Serum bilirubin \< 2.0 mg/dl * AST(aspartate aminotransferase,serum glutamate oxaloacetate transaminase, serum glutamate oxaloacetate transaminase,serum glutamate pyruvate transaminase)\[SGOT\]/ALT\[SGPT\]\<4 times institutional upper limit of normal * Total WBC(white blood cell)\>4,000/mm3 or ANC(absolute neutrophil count)\> 1,500/mm3 * Platelets \> 100,000/mm3 * Hgb \>10g/dl * Patient must have no clinically significant cardiac disease (New York Heart Association Class III/IV); no serious infection requiring treatment with antibiotics; no other serious ill-ness or illness requiring the use of steroids; no clinically significant pulmonary disease or other illness that would contraindicate or increase the risk of complications at surgery. * Fasting blood sugar less than 120 mg/dl Exclusion Criteria: * Patients with active CNS (central nervous system)tumor involvement are ineligible. * Any patient who has retained childbearing potential will not be pregnant or lactating and must use adequate contraception to assure avoidance of conception. * Body size prohibits use of the diagnostic equipment (portable CT scanner). * Tumor burden is so great (as determined by preoperative PET scanning or intraoperative findings) that further surgery is not advised. * If lesions are detected with preoperative CT but not with PET scanning (in other words, all patients will have a positive PET scan as part of the inclusion criteria).