Pistachios, Performance, Metabolomics

Appalachian State University40 enrolled

Overview

Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Inflammation Oxidative Stress Immune Dysfunction

Interventions

PistachiosOTHER

Eligibility

Sex: MALEMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male endurance cyclists * Capable of exercising for 2.5 h at a high intensity in the lab * Ages 18-55 * Agree to train normally and stay weight stable. * Agree to avoid the use of large dose vitamin/mineral supplements * Agree to avoid herbs and medications that influence inflammation Exclusion Criteria: * Regularly take supplements or medicines known to effect inflammation. * At moderate or high risk for cardiovascular disease. * Younger than 18 or older than 55 years of age. * No history of competing in cycling races.

Locations (1)

ASU Human Performance Laboratory, North Carolina Research Campus

Kannapolis, North Carolina, United States

Outcomes

Primary Outcomes

Shifts in metabolites (metabolomics)

Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Time frame: 14-day period

Secondary Outcomes

Inflammation

Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein

Time frame: 14-day period

Immune Function

Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential

Time frame: 14-day period

Oxidative Stress

Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes

Time frame: 14-day period

Data from ClinicalTrials.gov

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