14C-ARN-509 Microtracer Label AME and Absolute BA Study

Key Inclusion Criteria: 1. Gender : male 2. Age : 50 - 80 years, inclusive 3. Body Mass Index (BMI) : 18.5-30.0 kg/m2 4. Ability and willingness to abstain from alcohol, methylxanthine-containing beverages or food (coffee, tea, cola, chocolate, "power drinks"), grapefruit (juice) and tobacco products from 48 h prior to entry in the clinical research center until discharge 5. Medical history without major pathology Key Exclusion Criteria: 1. Evidence of clinically relevant pathology. 2. Mental handicap. 3. History of relevant drug and/or food allergies. 4. Regular/routine treatment with non-topical medications within 30 days prior to entry into the clinical research center. 5. Smoking. 6. History of alcohol abuse or drug addiction (including soft drugs like cannabis products). 7. Use of concomitant medication, except for acetaminophen (paracetamol) and topical medications 8. Irregular defecation pattern (less than once per 2 days). 9. Positive drug screen (opiates, methadone, cocaine, amphetamines, cannabinoids, barbiturates, benzodiazepines, and alcohol). 10. Intake of more than 24 units of alcohol per week (one unit of alcohol equals approximately 250 mL of beer, 100 mL of wine or 35 mL of spirits). 11. Positive screen on HBsAg, anti-HCV or anti-HIV 1/2. 12. Illness within five days prior to drug administration.