Childhood Body Composition and Brain Structure and Function

N/ACompletedNCT01822054

Arkansas Children's Hospital Research Institute27 enrolled

Overview

The specific aim of this research project is to use MRI methods to evaluate and compare brain structure and function in normal weight and obese children age 8-10 years.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Eligibility

Sex: ALLMin age: 8 YearsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy normal weight or obese children * Parental report of full-term gestation * Parental report of birth weight between 5th-95th percentiles * Parental report of breastfeeding or cow's milk formula fed during infancy * Right hand dominance Exclusion Criteria: * Maternal diabetes * Maternal alcohol, tobacco or drug use during pregnancy * Chronic sleep disorder * History of psychological or psychiatric diagnosis * History of neurological impairment or injury * Surgical implant or other foreign object in the body which may be a MRI safety concern * Dental work which may cause artifacts in MRI * Claustrophobia * High likelihood of inability to tolerate loud noise from the MRI scanner

Locations (1)

Arkansas Children's Nutrition Center

Little Rock, Arkansas, United States

Outcomes

Primary Outcomes

Brain structure

We will use high resolution volumetric MRI and DTIto measure the brain structure of these children

Time frame: 8 - 10 years of age

Secondary Outcomes

Brain Function

We will use high resolution fMRI to measure the brain function under different cognitive paradigms

Time frame: 8-10 years of age

Data from ClinicalTrials.gov

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