A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes

AHEPA University Hospital100 enrolled

Overview

This study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in patients with type 1 diabetes mellitus

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Autonomic Neuropathy

Interventions

metaiodobenzylguanidine scintigraphyRADIATION

Eligibility

Sex: ALLMin age: 20 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Type 1 diabetes mellitus Exclusion Criteria: * Type 2 diabetes mellitus * Severe cardiac autonomic neuropathy * Medications other than insulin * Ocular disease other than refractive eye disorders * History of neurologic disease * History of cardiovascular disease * Thyroid disease * Vitamin B insufficiency * Other possible cause for autonomic failure

Locations (1)

AHEPA hospital, First Propedeutic clinic of internal medicine

Thessaloniki, Thessaloniki, Greece

Outcomes

Primary Outcomes

number of participants with abnormal results

Time frame: 1 day (at time of examination)

Data from ClinicalTrials.gov

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