Physiological Response of Cortisol to Cardiac Catheterization

Creighton University24 enrolled

Overview

Cortisol is essential for survival. The importance of cortisol response is most apparent in patients with partial or complete deficiency of glucocorticoids during stressful events such as illness or surgery.

It is known that cortisol and other stress hormones increase during acute myocardial infarction as well (9-11). Cardiac catheterization is an essential tool for the management of acute coronary syndrome, and for the evaluation of the burden of coronary artery disease in cardiac patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Adrenal Insufficiency

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing elective cardiac catheterization, who are willing and able to give consent. Exclusion Criteria: * • Patients with .primary or secondary adrenal insufficiency. * Patients taking steroids in the doses equivalent of at least 5 mg of prednisone daily for more than 3 weeks in the previous year. * Patients undergoing cardiac catheterization in the setting of acute coronary syndrome, eg. STEMI, NSTEMI and unstable angina. * Patients with low albumin level (\<3.5 g/dL)

Locations (1)

Creighton University

Omaha, Nebraska, United States

Outcomes

Primary Outcomes

cortisol change

On the day of the procedure a total of 4 venous blood samples for random plasma cortisol level will be obtained. Blood will be drawn at 5 minutes prior to the procedure, at 30 minutes and 60 minutes during the cardiac catheterization. Another sample will be drawn in 3 hours after cardiac catheterization prior to the patients discharge. a cortisol level will be drawn at a "nonstressful" visit

Time frame: one month

Data from ClinicalTrials.gov

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