Influence of Protein Supplements on Serum Insulin-like Growth Factor-I Levels in Women With Anorexia Nervosa

Inclusion Criteria: * Women aged between 18 to 40 years (bounds included). * Women with a serum IGF-I level below the 25th percentile of the reference value according to the age (bounds included). * Women who had given written inform consent. * Women with DSM-IV-confirmed anorexia nervosa lasting for at least 6 months. Women with concomitant binge eating and purging type are also included. * Women admitted in-hospital for weight and nutritional rehabilitation. It is anticipated that the patient will stay in-hospital during the full duration of the 4-week supplementation phase, and at least 5 weeks within the study. * Women being already regular consumers of dairy products. * For women with childbearing potential, use of a contraceptive method. * Discontinuation of any mineral and vitamin supplements containing calcium and vitamin D, 1 week before starting the product consumption and during the study. Exclusion Criteria: * Women with primary amenorrhea; * Women with lactose intolerance; * Women with any other metabolic disease that could affect bone metabolism: osteogenesis imperfecta, Paget's disease of bone, hyperthyroidism, primary hyperparathyroidism; * Women with current or past neoplasm; * Women with any other severe comorbidity; * Pregnant or breast feeding women; * Women with epilepsy; * Women with any current or past use of the following treatments: bisphosphonates, calcitonin, steroids; * Patients enrolled in another clinical study within the last 4 weeks; * Patients having already received oral nutritional supplements or who need to receive other oral or intravenous (IV) supplements during the follow-up; * Patients having received oral or IV nutritional supplements within two weeks before the inclusion; * Patients having willed to participate in another clinical study during the present study phase and 4 weeks after the end of their participation in the present study.