FFR or OCT Guidance to RevasculariZe Intermediate Coronary Stenosis Using Angioplasty

Inclusion Criteria: * single vessel disease with an intermediate coronary artery stenosis * multivessel disease with multiple intermediate coronary artery stenosis only * multivessel disease with already treated angiographically critical stenosis and at least one intermediate coronary artery stenosis Exclusion Criteria: * age \<18 years or impossibility to give informed consent, * female sex with child-bearing potential, * life expectancy of less than 12 months or factors making clinical follow-up difficult (no fixed address, etc), * poor cardiac function as defined by left ventricular global ejection fraction ≤ 30% * recent (\< 7 days) ST-segment elevation myocardial infarction * recent (\< 48 hours) Non ST-segment elevation myocardial infarction * prior ST-segment elevation myocardial infarction in the territory supplied by the vessel with the intermediate stenosis under investigation * severe myocardial hypertrophy (interventricular septum thickness \> 15 mm, ECG Sokolow's criteria fulfilled) * severe valvular heart disease * significant platelet count alteration (\<100,000 cells/mm3 or \> 700,000 cells/mm3) * gastrointestinal bleeding requiring surgery or blood transfusions within 4 previous weeks * history of clotting pathology * known hypersensitivity to aspirin, heparin, contrast dye * advance renal failure with glomerular filtration rate \< 30 ml/min * lesions in coronary artery bypass grafts * multivessel disease requiring coronary aortic bypass graft intervention