The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation

Nanjing Medical University60 enrolled

Overview

Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

ARDS Intra-abdominal Hypertension

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * intra-abdominal hypertension * mechanical ventilation * sedation Exclusion Criteria: * underlying pulmonary disease * age older than 60 years and younger than 18 years * vital signs were not stable * non voluntary

Outcomes

Primary Outcomes

ventilator-free days

Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h.

Time frame: 28d

Secondary Outcomes

mortality

28-Day mortality include patients who giving up treatment due to critical condition