The Effect of GCSF in the Treatment of ALS Patients

Inclusion Criteria: * age between 18 and 85 * definite or probable ALS according to revised El Escorial criteria * maximum 2 years from initiation of symptoms to study entry * mild to moderate disability according to revised ALS functional rating scale (ALSFRS-r) Exclusion Criteria: * familial ALS * pregnancy or lactation * myeloproliferative or hematologic disorders * active immunological disease * liver or renal or heart disease * HIV positive * significant cognitive disorder * hypersensitivity to GCSF