The objective of the study is to investigate the drug interaction between Gemigliptin and Irbesartan by comparing pharmacokinetics of Gemigliptin and Irbesartan administered concomitantly and each alone in healthy male subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
30
Asan Medical Center
Seoul, South Korea
Cmax,ss
To evaluate Cmax,ss of Gemigliptin and Irbesartan
Time frame: up to 72h post-dose
AUCτ,ss
To evaluate AUCτ,ss of Gemigliptin and Irbesartan
Time frame: up to 72h post-dose
Cmin,ss
To evaluate Cmin,ss of Gemigliptin and Irbesartan
Time frame: up to 72h post-dose
Tmax,ss
To evaluate Tmax,ss of Gemigliptin, Irbesartan and LC15-0636 (active metaboilite of Gemigliptin)
Time frame: up to 72h post-dose
Cmax,ss
To evaluate Cmax,ss of LC15-0636 (active metaboilite of Gemigliptin)
Time frame: up to 72h post-dose
AUCτ,ss
To evaluate AUCτ,ss of LC15-0636(active metabolite of Gemigliptin)
Time frame: up to 72h post-dose
metabolic ratio
To evaluate metabolic ratio of LC15-0636(active metabolite of Gemigliptin)
Time frame: up to 72h post-dose
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