Soft Tissue Graft for Repair of Pelvic Organ Prolapse

Inclusion Criteria: * Patients in need of transvaginal surgical repair of primary (i.e., de novo) pelvic organ prolapse. * POPQ = stage 2 or 3 in the vaginal compartment with the leading edge of prolapse (i.e., more severe prolapse) * At least one symptom associated with prolapse (e.g., any of the following including but not limited to vaginal bulge, vaginal pain/discomfort, voiding dysfunction, manual reduction (digitation) needed for defecation, fecal incontinence, dyspareunia) Exclusion Criteria: * Age \< 18 years * BMI \> 40 * Not medically fit for transvaginal surgery under general or spinal anesthesia * Active UTI at the time of the index procedure as determined by urine culture * Vaginal atrophy (Note: Patient may be included after vaginal atrophy has been effectively treated.) * Prior placement of synthetic mesh or biologic graft for pelvic organ prolapse * A history of cervical, ovarian, uterine, endometrial, vaginal, vulval, colon, rectal or bladder cancer * Currently planned obliterative surgical repair for pelvic organ prolapse * Systemic infection at the time of surgery * Requires chronic immunosuppressive therapy, including steroids or cytotoxic agents * Pregnant, breastfeeding or planning pregnancy during the study period * Previous diagnosis of collagen disorder (i.e., Marfan's, Ehlers-Danlos) * Physical allergies or cultural objections to the receipt of porcine products * Life expectancy of less than 12 months * Ongoing participation in an investigational device or drug trial * Currently undergoing evaluation or treatment for chronic pelvic pain (e.g., pain as a result of interstitial cystitis, endometriosis, vulvodynia, pelvic congestion syndrome) * Active vaginal infection at the time of the index procedure * History of pelvic inflammatory disease