Feasibility Study of Ablathermy Focused Ultrasound (USF) of Breast Tumors Before Mastectomy

Inclusion Criteria: * Invasive Breast Carcinoma with histologically confirmed hormone receptor analysis, the grade of the tumor, the expression of Her-2. * Lesion classified T1-T2-T3 unifocal or multifocal with or without associated microcalcifications * Lesion recognizable and identifiable in MRI * Indication of mastectomy with or without axillary * Lesion located more than 10 mm from the skin, the nipple and pectoralis major * No cons-indication to MRI (pacemaker) * Women whose age is ≥ 18 years * If premenopausal patient: patient contraceptives * Patient has signed informed consent * Affiliation to a social security scheme Exclusion Criteria: * Tumor-TD T4B classified or non-palpable lesion * If age \<70 years: no indication of adjuvant chemotherapy and neoadjuvant * MRI lesions have not been identified, located within 10 mm of the skin and pectoral muscle, greater than 25 mm diameter * Inability to hold still in the prone position, arms extended, for 30 minutes * Contraindication to MRI * Patient deprived of liberty and major subject of a measure of legal protection or unable to consent * Patient participating in another interventional clinical trial within 30 days prior to baseline and during the trial.