A Phase III Study of Re-Irradiation in Recurrent Glioblastoma

Inclusion Criteria: * histologically-proven intracranial glioblastoma or gliosarcoma previously treated with concurrent chemoradiation * radiographic evidence of tumour progression or recurrence * 18 years or older * ECOG 0 - 2 * signed informed consent form Exclusion Criteria: * tumour progression or recurrence within 3 months of initial concurrent chemoradiation * 6 or more cycles of TMZ administered following chemoradiation at initial diagnosis * more than one prior course of salvage chemo for recurrent disease * prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for greater or equal to 3 years * prior head or neck RT except for T1 glottic cancer