The Safety, Immunogenicity and Immune Effect Research of the Varicella Vaccine After the 2nd Dose Vaccination

Beijing Center for Disease Control and Prevention50,000 enrolled

Overview

To investigate the safety, immunogenicity and immune effect of the Varicella vaccine after the 2nd dose vaccination in Chao yang district, Bei jing, since the 2nd varicella vaccination was promoted by Beijing Center for Disease Control and Prevention in November, 2012.

"Breakthrough" varicella cases and varicella cases were monitored to evaluate the protective effective in a large population. Make the basic evaluation of safety for the two dose of varicella vaccination Monitoring the Varicella virus origin and virus types from illness cases in Chao yang district Make the evaluation of healthy costs reduce for the varicella emergency vaccination after large number of varicella cases occurred.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

50,000

Conditions

Varicella

Interventions

varicella vaccineBIOLOGICAL

The providers would get varicella vaccine

Eligibility

Sex: ALLMin age: 4 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants were between 4-12 years old * Participants were in good healthy determined through medical history, physical examination, clinical judgment of the investor Exclusion Criteria: * Having a fever (axillary temperature \>37.0℃) before enrollment; * Having a disease history of seizures, brain and mental disease and the vaccination history of allergies and convulsions; * Antibiotics allergy; * Having a problem of intramuscular injection because thrombocytopenia or other blood coagulation disorder; * Having immunodeficiency or under immunosuppression therapy, radiation therapy; * Having respiratory diseases, acute infection, chronic disease and HIV infection; * Having systemic skin rash, skin tinea, herpes; * Chronic liver and kidney disease; * Heart disease, and severe hypertension; * Have received whole blood, plasma or immunoglobulin therapy 3 months before enrollment; * Have not received other vaccination in 7 days before enrollment

Locations (1)

Beijing Chaoyang District Centers for Disease Control and Prevention

Beijing, China

Outcomes

Primary Outcomes

Incidence of varicella after 2 dose vaccination

Detection the Varicella virus origin and virus types from illness cases in Chao yang district

Time frame: 5 years

Secondary Outcomes

Adverse event rate of varicella vaccine after 2 dose injection

Time frame: 5 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.