Collagen Cross-linking in Infectious Keratitis Trial

Phase 2CompletedNCT01831206

Chulalongkorn University30 enrolled

Overview

The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Infectious Keratitis Bacterial Keratitis Fungal Keratitis

Interventions

Collagen cross-linkingPROCEDURE

Collagen cross-linking arm will receive standard medication for corneal ulcer treatment and corneal collagen cross-linking. Standard treatment arm will receive only standard medication.

Eligibility

Sex: ALLMin age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Evidence of corneal ulcer grade II or III (bacteria or fungal, or presumed bacterial or fungal) * Age more than 6 year * Patients can understand and can follow the study protocol Exclusion Criteria: * Pregnancy by history or urine test * Evidence of herpetic keratitis * Evidence of corneal perforation * Evidence of autoimmune disease * Known allergy to study medication

Locations (1)

Ophthalmology department, King Chulalongkorn Memorial hospital

Pratumwan, Bangkok, Thailand

Outcomes

Primary Outcomes

decrement of infiltration size

decrement of infiltration size between day0 and day 30

Time frame: 1 months

Secondary Outcomes

number of participants with adverse events

adverse events after corneal collagen cross-linking (report in descriptive study)

Time frame: 1 months

Data from ClinicalTrials.gov

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