Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients

Inclusion Criteria: 1. Male and female patients older than 13 years of age 2. Presenting with 1 to 3 aphthous ulcers (less than 48 hours' duration) with a size no greater than 5mm in diameter. 3. History of recurrent minor aphthous ulcer for at least one year with a frequency of at least one outbreak every one month. 4. Normal sense of pain, without anesthesia or paresthesia. 5. Willingness to participate and sign the informed consent. Exclusion Criteria: * 1- Concurrent clinical conditions that could pose a health risk to the subjects including serious heart, liver, or kidney dysfunctions. 2- Pregnancy and lactation. 3- Ulcers as a manifestation of systemic disorders such as Ulcerative Colitis, Crohn's disease, Behçet's syndrome or serious anemia. 4- Treatment with systemic steroids, immunomodulatory agents, antibiotics, non-steroidal anti-inflammatory drugs (except occasional use for headaches) one month prior to the study entry. 5- Treatment of the current ulcer with any topical or systemic medication. 6- Attendance of any other clinical trials prior to 3 months of study entry.